Research experience

2016.10 - present

Identification of genetic and modifiable risk factor for human complex traits and diseases
PhD student (Supervisor: Prof. Jian Yang, Institute for Molecular Bioscience & Queensland Brain Institute)

• Genome-wide association studies on the genetic architecture of type 2 diabetes [Publication]

• Investigate the influence of misreporting and longitudinal changes in the genetic analysis for self-reported behavioural traits [Preprint]

• Analysing different substance use behaviours like drinking, smoking, and investigating their causal effects for human complex diseases

• Improved the algorithm and R package for a software tool of Mendelian Randomization [Software link]

• Revealing the regulatory pathway and biological network of basal cell carcinoma

2015.8 - 2016.9

Dissecting genetic architecture using multi-omics information: A case of GWAS for startle behaviour in Drosophila melanogaster

Research assistant (Mentor: Prof. Jun Zhu, Institute of Bioinformatics)

• Analyzed the multi-omics data to detect SNPs and eQTLs associated with startle behaviour in Drosophila (fruit fly) [Publication]

• Investigated the evolutionary conservation of key genes and pathways between Drosophila and human

2014.8 - 2015.6

Association mapping of genetic network for plant morphology traits in Upland cotton

Undergraduate dissertation (Mentor: Prof. Jun Zhu, Institute of Bioinformatics)

• Dissected genetic basis of plant morphology traits and branch architecture traits in upland cotton [Publication]

• Provided new cotton breeding strategies using associated SSR markers [Publication]

2014.7.7 - 8.17

DMT Resistance Measurement and Mutant Screening of Phytophthora capsici

Summer Research Apprenticeship in University of Illinois at Urbana-Champaign

(Mentor: Prof. Mohammad Babadoost, Department of Crop Sciences)

· Measured the sensitivities of a list of Phytophthora capsici isolates from pumpkins in Illinois to a fungicide dimethomorph by determining EC50 of colony diameter growth

2013.3 - 2014.3

The Ghost Kit——Detect, Purify, and Store Protein

Team Leader of International Genetically Engineered Machine (iGEM) competition team

(Instructor: Prof. Ming Chen, Department of Bioinformatics)

Website: http://2013.igem.org/Team:ZJU-China

• In charge of all teamwork and co-supervised the project

• Designed four new parameters used to describe RNA aptamer-based riboswitch, and made quantitative and qualitative descriptions of them in the form of standardized datasheet and graph

2012.3 - 2013.3

V2 of tomato yellow leaf curl virus can suppress methylation-mediated transcriptional gene silencing in plant

Research assistant (Mentor: Prof. Xueping Zhou, State Key Laboratory of Rice Biology)

• Learned some basic skills of molecular experiment, such as plasmid DNA extraction and PCR

• Demonstrated that the tomato yellow leaf curl virus (TYLCV) V2 protein can reverse TGS by reducing the methylation levels in the 35S promoter sequence

Conference presentation

International Conference of Quantitative Genetics 6^th. 2020, 2-13 November (upcoming), Brisbane, Australia.

Poster presentation: Genome-wide analyses of behavioral traits biased by misreports and longitudinal changes

The International Young Scholars Forum of Sun Yat-sen University. 2019, 26-28 December, Guangzhou, China.

Invited talk: Genome-wide association studies on human complex traits based on multi-omics data

The Symposium of Quantitative Genetics. 2019, 24-26 May. Hangzhou, China.

Invited talk: Genetic risk variants and putative regulatory mechanisms for type 2 diabetes

Quantitative Genetics and Genomics, Gordon Research Conference & Seminar. 2019, 08-15 February, Lucca, Italy

Poster presentation: The health consequences of tobacco smoking, alcohol, coffee and tea drinking behaviors

GeneMappers, 2018. 29-31, August, Noosa Heads, Queensland, Australia

Poster presentation: Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

FHS-OMICS Conference Series (video-conferencing), 2018, 10 February, Boston, USA.

Organized by Framingham Heart Study (FHS) Conference Committee.

Invited talk: Genetic risk variants and putative regulatory mechanisms for type 2 diabetes.

Peer review activity

• Early Career Reviewer in Statistical Genetics & Genomics section, GENETICS

• The GENETICS Peer Review Training Program (2019.6 - 2019.7)

• Clinical Obesity (2020)

• Genetics (2019, 2020 x 2)

• Journal of Human Genetics (2019)

• EBioMedicine (2018, Outstanding Contribution in Reviewing Award)

• Nucleic Acids Research (2018, 2019)

• Publons ID: 1390585